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SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
USERS' SCORE
Good
Based on 10 Reviews
8.8
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
30
Total Fat
2.5 g
3%**
Cholesterol
<5 mg
1%
Protein
<1 g
Vitamin E (as natural d-alpha tocopherol)
13.4 mg
89%
Norwegian Fish Oil
2.5 g
†
Total Omega-3 Fatty Acids*
1,600 mg
†
EPA (Eicosapentaenoic Acid)*
800 mg
†
DHA (Docosahexaenoic Acid)*
600 mg
†
Top Medical Research Studies
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Directly addresses eicosapentaenoic acid
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
Read More
9
Eicosapentaenoic Acid aids autoimmunity
ω-3 polyunsaturated fatty acid alleviates systemic lupus erythematosus by suppressing autoimmunity in a murine model.
Highly relevant autoimmune research
We explored the effect of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on systemic lupus erythematosus (SLE), a complex autoimmune disease that causes widespread inflammation in the body. In a carefully designed study using a mouse model of SLE, we discovered that dietary supplementation with EPA-rich fish oil significantly improved various autoimmune symptoms.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Read More
9
Eicosapentaenoic acid aids lupus management
Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity.
Highly relevant to autoimmune research
We sought to understand how dietary fatty acids, specifically eicosapentaenoic acid (EPA), influence autoimmune diseases like lupus. Through our research on both drug-induced and spontaneous mouse models of lupus, we observed that supplementing with EPA significantly eased symptoms associated with the disease.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Read More
Most Useful Reviews
9.5
Inflammation reduction
I have tried many omega brands, and this one is my favourite. Two cans arrived, and following the instructions for 2 capsules a day meant it would last exactly two months—a budget-friendly choice. I experience a slight burp, but it’s citrus, not fishy. The quality is excellent; my hair and nails improved. After COVID, I felt slightly depressed, but this omega resolved that issue effectively. It’s well packed, and the capsules are large yet easy to swallow. For anyone needing omega, this is a godsend! It effectively reduces inflammation for my autoimmune disorder.
Read More
9.5
Mood enhancement
This is the best omega I've tried! It comes in two cans, lasting two months with two capsules daily. I appreciate the absence of fishy burps—just citrus. My hair, nails, and mood improved significantly after I struggled with depression post-COVID. The capsules are large but easy to swallow. For anyone requiring omega, this is a fantastic choice that effectively alleviates inflammation for my autoimmune disorder.
Read More
9.5
Heart health restoration
A must for women! At 46, I've taken Omega-3 consistently for five years but took a three-month break. I faced heart issues and dry skin, realising I neglected my health. I ordered omega-3 and some vitamins, and I felt human again! Omega-3 regulates cholesterol, and its benefits are apparent. The large, easy-to-swallow capsules lack an unpleasant taste, reflecting high-quality ingredients.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
9
Eicosapentaenoic Acid aids autoimmunity
ω-3 polyunsaturated fatty acid alleviates systemic lupus erythematosus by suppressing autoimmunity in a murine model.
Highly relevant autoimmune research
We explored the effect of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on systemic lupus erythematosus (SLE), a complex autoimmune disease that causes widespread inflammation in the body. In a carefully designed study using a mouse model of SLE, we discovered that dietary supplementation with EPA-rich fish oil significantly improved various autoimmune symptoms.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Read More
9
Combination therapy shows promise
Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid.
Moderate relevance to autoimmune treatment
We set out to understand if adding eicosapentaenoic acid (EPA) to ursodeoxycholic acid (UDCA) could improve outcomes for patients with autoimmune disorders and cholestatic liver diseases. By evaluating how this combination affects key factors like bile acid management, cell apoptosis, and inflammation, we aimed to see if EPA could bolster the effects of UDCA, especially in patients who typically do not respond well to this treatment.
Interestingly, we found that when EPA was combined with a lower dose of UDCA, the results were quite appealing. The combination helped reduce the expression of certain inflammatory genes and showed a notable decrease in cell damage caused by bile acids, even when compared to higher doses of UDCA alone. This means that with EPA, we could potentially achieve better therapeutic outcomes without escalating the drug dosage.
Our findings suggest that incorporating EPA alongside UDCA not only enhances the benefits but could also widen the therapeutic window for patients struggling with liver issues linked to autoimmune disorders. This exciting pharmaco-nutraceutical approach may pave the way for more effective treatments in the future.
Interestingly, we found that when EPA was combined with a lower dose of UDCA, the results were quite appealing. The combination helped reduce the expression of certain inflammatory genes and showed a notable decrease in cell damage caused by bile acids, even when compared to higher doses of UDCA alone. This means that with EPA, we could potentially achieve better therapeutic outcomes without escalating the drug dosage.
Our findings suggest that incorporating EPA alongside UDCA not only enhances the benefits but could also widen the therapeutic window for patients struggling with liver issues linked to autoimmune disorders. This exciting pharmaco-nutraceutical approach may pave the way for more effective treatments in the future.
Read More
9
Eicosapentaenoic acid aids lupus management
Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity.
Highly relevant to autoimmune research
We sought to understand how dietary fatty acids, specifically eicosapentaenoic acid (EPA), influence autoimmune diseases like lupus. Through our research on both drug-induced and spontaneous mouse models of lupus, we observed that supplementing with EPA significantly eased symptoms associated with the disease.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Read More
9
Eicosapentaenoic acid's role in arthritis
CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota.
Relevant but not conclusive effects
We aimed to understand how eicosapentaenoic acid, among other metabolites, plays a role in managing autoimmune disorders like rheumatoid arthritis (RA). We tested two specific strains of probiotics, CCFM1074 and CCFM1075, on rats with collagen-induced arthritis to evaluate their impact on immune responses and gut health.
Our findings showed that CCFM1074 significantly eased symptoms of arthritis, while CCFM1075 did not offer similar benefits. Interestingly, both strains helped reduce inflammation markers, notably lowering plasma levels of IL-6 and decreasing the proportion of harmful Th17 cells. However, CCFM1074 stood out by increasing beneficial Treg cells in the mesenteric lymph nodes.
One of the highlights of our study was the role of eicosapentaenoic acid—a metabolite that was notably regulated by CCFM1074. This fatty acid is linked to improving unsaturated fatty acids metabolism, which may contribute to reducing arthritis symptoms. Additionally, CCFM1074 positively influenced the gut microbiota, altering community structures and enhancing beneficial bacteria populations.
Overall, we observed that eicosapentaenoic acid, alongside other factors, could help alleviate arthritis by promoting a healthier gut environment and balancing immune responses.
Our findings showed that CCFM1074 significantly eased symptoms of arthritis, while CCFM1075 did not offer similar benefits. Interestingly, both strains helped reduce inflammation markers, notably lowering plasma levels of IL-6 and decreasing the proportion of harmful Th17 cells. However, CCFM1074 stood out by increasing beneficial Treg cells in the mesenteric lymph nodes.
One of the highlights of our study was the role of eicosapentaenoic acid—a metabolite that was notably regulated by CCFM1074. This fatty acid is linked to improving unsaturated fatty acids metabolism, which may contribute to reducing arthritis symptoms. Additionally, CCFM1074 positively influenced the gut microbiota, altering community structures and enhancing beneficial bacteria populations.
Overall, we observed that eicosapentaenoic acid, alongside other factors, could help alleviate arthritis by promoting a healthier gut environment and balancing immune responses.
Read More
9
DHA mediators reduce RA symptoms
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Mixed effects observed in study
We explored how lipid mediators derived from docosahexaenoic acid (DHA) impact rheumatoid arthritis (RA), an autoimmune disorder marked by inflammation and joint damage. In our investigation, we noted that a specific combination of lipid mediators produced from DHA, including 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX, showed promise in reducing arthritis severity.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.8
9.5
Inflammation reduction
I have tried many omega brands, and this one is my favourite. Two cans arrived, and following the instructions for 2 capsules a day meant it would last exactly two months—a budget-friendly choice. I experience a slight burp, but it’s citrus, not fishy. The quality is excellent; my hair and nails improved. After COVID, I felt slightly depressed, but this omega resolved that issue effectively. It’s well packed, and the capsules are large yet easy to swallow. For anyone needing omega, this is a godsend! It effectively reduces inflammation for my autoimmune disorder.
Read More
9.5
Mood enhancement
This is the best omega I've tried! It comes in two cans, lasting two months with two capsules daily. I appreciate the absence of fishy burps—just citrus. My hair, nails, and mood improved significantly after I struggled with depression post-COVID. The capsules are large but easy to swallow. For anyone requiring omega, this is a fantastic choice that effectively alleviates inflammation for my autoimmune disorder.
Read More
9.5
Joint pain relief
This is the best omega-3 I've taken. There was no gastrointestinal discomfort or belching; I didn’t notice a taste. Many doctors recommend this omega because of its optimal EPA and DHA ratio. After one month, my skin improved and joint pain disappeared post-activity. I recommend this omega and will continue ordering it.
Read More
9.5
Heart health restoration
A must for women! At 46, I've taken Omega-3 consistently for five years but took a three-month break. I faced heart issues and dry skin, realising I neglected my health. I ordered omega-3 and some vitamins, and I felt human again! Omega-3 regulates cholesterol, and its benefits are apparent. The large, easy-to-swallow capsules lack an unpleasant taste, reflecting high-quality ingredients.
Read More
8.8
Body condition improvement
Excellent fish oil. I've taken it for a month and noticed a marked difference; I wake up more easily and feel better overall! The benefits of fish oil are undeniable, it's crucial to choose a quality product. This company impressed me, and I will order more.
